A couple years back I had some really terrible RSI that forced me to take time off work. I went to hand specialist and they gave me a series of exercises to do every couple hours. A few wrist stretches, but a lot of it was shoulder and back exercises. I alternated between mouse and wacom, but for me, posture was the core problem. Some people do fine with using just a mouse for their entire careers with little to no physical issues. I think this is an issue less about the actual device you're using and more about your overall ergonomics. Here's a couple important ones off the top of my head
Your monitor should be at eye level.
Your shoulders should be squared to your workstation, and your hands shoulder width apart.
Your elbows should be supported and around a 90 degree angle.
Your hands should be flush with your wrists. If they're at an angle above or below, you're likely putting unnecessary strain on them, especially in your idling moments.
Your feet should be flat on the ground, and your knees at approximately 90 degrees
Your back should be straight, and you should have back support to fall back on that lets you retain the above requirements